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All authors have given final approval of the version to be published.Colonoscopy is an effective approach to detect and remove the precancerous lesions2 and issued data well demonstrate that successful implementation of colonoscopy can reduce 50 mortality rate of CRC.3,4 Consequently, the colonoscopy technique has been recommended to screen and treat CRC.2 Significantly, however, adequate bowel preparation plays a key role in successful implementation of colonoscopy and is the guarantee of proper screening efficacy.5 Published studies revealed that 20 to 25 inadequate bowel preparations were caused mainly by low patient-based compliance, poor palatability of bowel preparation solution, and large volume preparation solution.6,7 It should be noted that, however, low patient-based compliance is the critical one in numerous reasons of causing inadequate bowel preparation.8,9 Clear liquid diet (CLD) is an established modified regime of normal diet, which do not include any solids, milk, and fruit juices containing pulp.10 Traditionally, CLD is extensively adopted to perform bowel preparation on the day prior to colonoscopy.5 However, these shortages of the bowel preparation regime, suchwww.md-journal.com |DMedicineVolume 95, Number 1, JanuarySong et alMedicineVolume 95, Number 1, Januaryas too restrictive, containing insufficient calories and high risk of causing several adverse events (AEs), significantly impair the patient-based compliance.11,12 To It would appear that a higher proportion of RB address these issues existed in CLD regime, Dehyde [31 and, as such, might be expected to exhibit widespread expression] researchers and clinical practitioners explored some novel bowel preparation regimes, of which low-residue diet (LRD) regime is increasingly concerned. All authors have given final approval of the version to be published.Colonoscopy is an effective approach to detect and remove the precancerous lesions2 and issued data well demonstrate that successful implementation of colonoscopy can reduce 50 mortality rate of CRC.3,4 Consequently, the colonoscopy technique has been recommended to screen and treat CRC.2 Significantly, however, adequate bowel preparation plays a key role in successful implementation of colonoscopy and is the guarantee of proper screening efficacy.5 Published studies revealed that 20 to 25 inadequate bowel preparations were caused mainly by low patient-based compliance, poor palatability of bowel preparation solution, and large volume preparation solution.6,7 It should be noted that, however, low patient-based compliance is the critical one in numerous reasons of causing inadequate bowel preparation.8,9 Clear liquid diet (CLD) is an established modified regime of normal diet, which do not include any solids, milk, and fruit juices containing pulp.10 Traditionally, CLD is extensively adopted to perform bowel preparation on the day prior to colonoscopy.5 However, these shortages of the bowel preparation regime, suchwww.md-journal.com |DMedicineVolume 95, Number 1, JanuarySong et alMedicineVolume 95, Number 1, Januaryas too restrictive, containing insufficient calories and high risk of causing several adverse events (AEs), significantly impair the patient-based compliance.11,12 To address these issues existed in CLD regime, researchers and clinical practitioners explored some novel bowel preparation regimes, of which low-residue diet (LRD) regime is increasingly concerned. LRD is also a modified regime of normal diet, which contain daily